Trip to Santiago city centre from the airport:
The Santiago airport is 10 kilometres from the city. The best way to get there is by bus, which in 30 minutes and for 3€ (5.10€ round trip) leaves you in the centre of Santiago. To get to the bus stop, follow the signs for "Bus Santiago" in the airport (not the signs for "Bus Tour Operador"). The bus leaves every 30 minutes from 12:00am to 11:30pm and makes stops at the bus station, the train station and the city centre (Calle Doctor Teixeiro). Get off at the stop closest to your hotel and walk or take a taxi (4-5€).
If you prefer, you can take a taxi directly from the airport to your hotel (15 minutes, 20€).